General
Preferred name
SDZ-SER-082
Synonyms
SDZ SER 082 fumarate ()
SDZ SER-082 ()
P&D ID
PD049975
CAS
141474-54-6
1417343-80-6
Tags
available
drug candidate
Drug indication
Neurological disorder
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Selective 5-HT2B/2C antagonist
(Tocriscreen Total)
DESCRIPTION
SDZ SER 082 fumarate is a selective 5-HT2B/2C receptor antagonist with low affinity for 5-HT1A receptors. SDZ SER 082 fumarate inhibits [3H]-mesulergine binding to 5-HT2C receptors (pKD = 7.8), and suppresses 5-HT2B mediated responses in the rat fundus (pKB = 7.34).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
BOC Sciences Bioactive Compounds
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
228.16
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
1
cLogP
2.1
TPSA
6.48
Fraction CSP3
0.6
Chiral centers
2.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
HTR2A, HTR2B, HTR2C
MOA
serotonin receptor antagonist
Source data
