General
Preferred name
Ro60-0175
Synonyms
Ro 60-0175 fumarate ()
Ro 60-0175 ()
Ro-60-0175 ()
Ro60-0175 (fumarate) ()
P&D ID
PD049972
CAS
169675-09-6
169675-08-5
Tags
available
drug candidate
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ro60-0175 fumarate is a potent and selective agonist of 5-HT2C receptor[1].
DESCRIPTION
Ro60-0175 is a potent and selective agonist of 5-HT2C receptor. Ro60-0175 reduces self-administration[1].
PRICE
211
DESCRIPTION
Selective 5-HT1A agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent, selective 5-HT2C agonist
(Tocriscreen Plus)
DESCRIPTION
Potent, selective 5-HT2C agonist
(Tocriscreen Total)
DESCRIPTION
Ro 60-0175 fumarate is a potent and selective SR-2 agonist. It is a potent, selective 5-HT2 receptor agonist, with selectivity for the 5-HT2C subtype (pKi= 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Ro60-0175 a selective agonist for both the 5-hydroxytryptamine 2B (5-HT2B) and 5-hydroxytryptamine 2C (5-HT2C)serotonin receptor subtypes, commonly used as fumarate salt. It has a role as a 5-hydroxytryptamine 2B receptor agonist and a 5-hydroxytryptamine 2C receptor agonist.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
EUbOPEN Chemogenomics Library
Guide to Pharmacology
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
226.07
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
2.78
TPSA
30.95
Fraction CSP3
0.27
Chiral centers
1.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
5-HT2C
HTR2A, HTR2B, HTR2C
5-HT Receptor
5-HT2C agonist
Primary Target
5-HT2C Receptors
MOA
Agonist
serotonin receptor agonist
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Recommended Cell Concentration
100 nM
Source data
