General
Preferred name
PF-4840154
Synonyms
PF 4840154 ()
PF4840154 ()
P&D ID
PD049739
CAS
1332708-14-1
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PF-4840154 has been foundd to be superior than Mustard Oil as a TrpA1 agonists. IC50: 97 nM and 23 nM (EC50) for hTrpA1 and rTrpA1 respectively. (BOC Sciences Bioactive Compounds)
Compound Sets
7
BOC Sciences Bioactive Compounds
pf-4840154-cas-1332708-14-1-item-474479
Cayman Chemical Bioactives
28915
Concise Guide to Pharmacology 2023/24
6309
DrugMAP
DMI29ED
Guide to Pharmacology
6309
MedChem Express Bioactive Compound Library
HY-18779
TargetMol Bioactive Compound Library
T4385
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
466.31
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
2
cLogP
3.02
TPSA
82.62
Fraction CSP3
0.58
Chiral centers
1.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
rTRPA1
hTRPA1
TRP Channel
MOA
TRP/TRPV Channel
Solubility
10 mM in DMSO
Source data