General
Preferred name
ZK-93426
Synonyms
ZK 93426 hydrochloride ()
ZK93426 ()
P&D ID
PD049685
CAS
89592-45-0
Tags
available
drug candidate
Drug indication
Alzheimer disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Potent, competitive benzodiazepine antagonist (Tocriscreen Plus)
DESCRIPTION Potent, competitive benzodiazepine antagonist (Tocriscreen Total)
Compound Sets
10
Concise Guide to Pharmacology 2017/18
4347
Concise Guide to Pharmacology 2019/20
4347
Concise Guide to Pharmacology 2021/22
4347
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMMDQ5T
Guide to Pharmacology
4347
ReFrame library
Tocriscreen Plus
1996
Tocriscreen Total
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
312.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
3.99
TPSA
64.21
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.74
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Target
GABRA1, GABRA2, GABRA3, GABRA5
MOA
benzodiazepine receptor antagonist
Source data