General
Preferred name
OLICERIDINE
Synonyms
CHEMBL2443262 ()
TRV130 (hydrochloride) ()
Oliceridine hydrochloride ()
TRV-130 ()
Olinvyk ()
TRV130 ()
Olynvik ()
TRV-130 (hydrochloride) ()
P&D ID
PD049656
CAS
1401031-39-7
1401028-24-7
Tags
drug
probe
biased GPCR ligand
available
Approved by
FDA
First approval
2020
Drug Status
investigational
approved
Drug indication
Acute pain
Thyroid disease
Max Phase
Phase 4
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
Probe sources
Tool Compound Set
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
3
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Oliceridine (TRV130) is an opioid compound. It was developed to exhibit biased-signalling (specifically bias towards G protein signalling), with the aim of reducing the adverse effects associated with use of other opioid drugs .
(GtoPdb)
DESCRIPTION
Oliceridine (TRV130) is an opioid compound. This compound has been developed to exhibit biased-signalling, with the aim of reducing the adverse effects associated with use of other opioid drugs .
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
BiasDB
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
ReFrame library
TargetMol Bioactive Compound Library
Tool Compound Set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
386.2
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
2
cLogP
4.69
TPSA
43.38
Fraction CSP3
0.59
Chiral centers
1.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Mu opioid receptor
??-opioid receptor
OPRM1
Pathway
Endocrinology/Hormones
GPCR/G protein
Neuroscience
MOA
Opioid Receptor agonist
VGSC Target
Nav1.5
Source data
