General
Preferred name
calindol
Synonyms
Calindol (hydrochloride) ()
Calindol hydrochloride ()
P&D ID
PD049598
CAS
374933-30-9
729610-18-8
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION The calcium sensing receptor (CaSR) has a long amino terminal tail typical of family 3 of GPCRs including the metabotropic glutamate receptors, the c-aminobutyric acid B receptor and certain pheromone and taste receptors. Calindol hydrochloride is a new calcimimetic compound acting as (CaSR). It is a positive allosteric modulator of the human Ca2+ receptor which activates an extracellular ligand-binding domain-deleted, Rhodopsin-like, seven-transmembrane structure in the absence of Ca2+. Calindol is used to study the properties and distribution of CaSR in different types of cells and tissues. (BOC Sciences Bioactive Compounds)
Compound Sets
9
BOC Sciences Bioactive Compounds
calindol-hydrochloride-cas-729610-18-8-item-118159
Cayman Chemical Bioactives
17575
Concise Guide to Pharmacology 2017/18
719
Concise Guide to Pharmacology 2019/20
719
Concise Guide to Pharmacology 2021/22
719
Concise Guide to Pharmacology 2023/24
719
DrugMAP
DMY9P6E
Guide to Pharmacology
719
MedChem Express Bioactive Compound Library
HY-122819
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
300.16
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
4
cLogP
5.17
TPSA
27.82
Fraction CSP3
0.14
Chiral centers
1.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Target
CaSR
Solubility
Soluble to ≤15mg/ml in ethanol, to 50mg/ml in DMSO, to 50mg/ml in dimethyl formamide.
Source data