General
Preferred name
MRE 3008F20
Synonyms
MRE3008F20 ()
[3H]MRE 3008F20 ()
MRE 3008F20 ()
P&D ID
PD049592
CAS
252979-43-4
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 208
DESCRIPTION MRE 3008F20 is a potent adenosine A3 receptor competitive antagonist, which is selective for human A3 receptors over human A1 and A2A receptors (Ki= 0.29, 141 and 1197 nM respectively). MRE 3008F20 has also been studied extensively in recent advances in adenosine receptor ligand in pulmonary diseases. (BOC Sciences Bioactive Compounds)
DESCRIPTION MRE3008F20 is a species-selective and potent adenosine A3 receptor (AA3R) antagonist that inhibits Cl-IB-MECA-induced cAMP production and can be used in glaucoma and asthma studies.13483-88-88-9 (TargetMol Bioactive Compound Library)
DESCRIPTION Selective positive allosteric modulator of mGlu2 receptors (Tocris Bioactive Compound Library)
Compound Sets
6
BOC Sciences Bioactive Compounds
mre-3008f20-cas-252979-43-4-item-170014
Cayman Chemical Bioactives
43169
DrugMAP
DM72US0
Guide to Pharmacology
477
459
TargetMol Bioactive Compound Library
T16132
Tocris Bioactive Compound Library
4041
External IDs
14
Properties
(calculated by RDKit )
Molecular Weight
432.17
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
5
Aromatic Ring Count
5
cLogP
3.8
TPSA
124.4
Fraction CSP3
0.19
Chiral centers
0.0
Largest ring
6.0
QED
0.42
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Adenosine Receptor
AA3R
cAMP
Primary Target
Adenosine A3 Receptors
MOA
Antagonist
Pathway
GPCR/G protein
Neuroscience
Source data