General
Preferred name
MRE 3008F20
Synonyms
MRE3008F20 ()
[3H]MRE 3008F20 ()
MRE 3008F20 ()
P&D ID
PD049592
CAS
252979-43-4
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 208
DESCRIPTION MRE 3008F20 is a potent adenosine A3 receptor competitive antagonist, which is selective for human A3 receptors over human A1 and A2A receptors (Ki= 0.29, 141 and 1197 nM respectively). MRE 3008F20 has also been studied extensively in recent advances in adenosine receptor ligand in pulmonary diseases. (BOC Sciences Bioactive Compounds)
DESCRIPTION Selective positive allosteric modulator of mGlu2 receptors (Tocris Bioactive Compound Library)
DESCRIPTION MRE3008F20 is a species-selective and potent adenosine A3 receptor (AA3R) antagonist that inhibits Cl-IB-MECA-induced cAMP production and can be used in glaucoma and asthma studies.13483-88-88-9 (TargetMol Bioactive Compound Library)
Compound Sets
6
BOC Sciences Bioactive Compounds
mre-3008f20-cas-252979-43-4-item-170014
Cayman Chemical Bioactives
43169
DrugMAP
DM72US0
Guide to Pharmacology
477
459
TargetMol Bioactive Compound Library
T16132
Tocris Bioactive Compound Library
4041
External IDs
73
Properties
(calculated by RDKit )
Molecular Weight
432.17
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
5
Aromatic Ring Count
5
cLogP
3.8
TPSA
124.4
Fraction CSP3
0.19
Chiral centers
0.0
Largest ring
6.0
QED
0.42
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Adenosine Receptor
AA3R
cAMP
Primary Target
Adenosine A3 Receptors
MOA
Antagonist
Pathway
GPCR/G protein
Neuroscience
Source data