General
Preferred name
Arachidonoyl amide
Synonyms
ARACHIDONAMIDE ()
P&D ID
PD049523
CAS
85146-53-8
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Arachidonamide (AEA) is a weak cannabinoid CB1 and CB2 agonist. Arachidonamide was hydrolyzed by FAAH more effectively than AEA but exhibited significantly weaker binding to the human CB1 receptor with a Ki of 9.6 μM. AEA also inhibits rat glial gap junction cell-cell communication by 90% at a concentration of 20 µM. Arachidonamide are found to be the best substrates for anandamide amidohydrolase (AAH) with relative rates of hydrolysis about twice that of anandamide.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
2
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
303.26
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
14
Ring Count
0
Aromatic Ring Count
0
cLogP
5.62
TPSA
43.09
Fraction CSP3
0.55
Chiral centers
0.0
Largest ring
0.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Solubility
Soluble in DMSO, DMF and ethanol (≤10mg/ml).
Source data
