General
Preferred name
DASOTRALINE
Synonyms
SEP 225289 ()
SEP-225289 hydrochloride ()
Dasotraline (hydrochloride) ()
DASOTRALINE HYDROCHLORIDE ()
Dasotralina ()
SEP-225289 ()
(1r,4s)-trans-norsertraline ()
Norsertraline, (1r,4s)-trans- ()
SEP-225289 HCI ()
(1S,4R)-N-Desmethyl Sertraline Hydrochloride ()
P&D ID
PD049483
CAS
675126-05-3
675126-08-6
675126-07-5
Tags
available
drug
drug candidate
Drug indication
Mood disorder
Attention deficit hyperactivity disorder
Eating disorder
Drug Status
approved
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Dasotraline is a triple reuptake inhibitor . Such compounds are also known as serotonin-norepinephrine-dopamine reuptake inhibitors, or SNDRIs. Structurally, dasotraline is a stereoisomer of an active metabolite of , a selective serotonin reuptake inhibitor (SSRI) antidepressant.
(GtoPdb)
DESCRIPTION
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
PRICE
48
PRICE
320
DESCRIPTION
(1S,4R)-N-DesmethylSertralineHydrochloride is a Serotonin transporter and Norepinephrine transporter inhibitor with IC50 of 19 nM and 35 nM, respectively.
DESCRIPTION
Dasotraline hydrochloride is a metabolite of sertraline and a novel inhibitor of dopamine and norepinephrine reuptake that blocks dopamine, norepinephrine, andserotonin transporters (IC50= 4, 6, and 11 nM, respectively).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that inhibits dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
291.06
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
4.92
TPSA
26.02
Fraction CSP3
0.25
Chiral centers
2.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Dopamine Transporter
Serotonin Transporter
5-HT
dopamine
Norepinephrine (NE)
Pathway
Neuronal Signaling
GPCR/G protein
Neuroscience
MOA
dopamine-norepinephrine-serotonin reuptake inhibitor
Source data
