General
Preferred name
AZD1386
Synonyms
AZD-1386 ()
Azd 1386 ()
P&D ID
PD049458
Tags
available
drug candidate
Drug indication
Esophagus sensitivity
Gastroesophageal reflux disease
Drug Status
investigational
Max Phase
Phase 2
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AZD1386 is an orally available antagonist of the transient receptor potential channel TRPV1. It acts as a competitive antagonist at the channel's capsaicin binding site .
This compound was in the AstraZeneca/MRC repurposing list from 2011 (GtoPdb)
Compound Sets
4
ChEMBL Drugs
CHEMBL3545039
DrugMAP
DMFAG8W
Guide to Pharmacology
7820
ReFrame library
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
423.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
3.25
TPSA
78.51
Fraction CSP3
0.21
Chiral centers
1.0
Largest ring
6.0
QED
0.57
QED
0.57
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Therapeutic Class
Analgesics
Source data