General
Preferred name
GW791343
Synonyms
GW791343 (trihydrochloride) ()
GW791343 (HCl) ()
GW 791343 dihydrochloride ()
GW 791343 trihydrochloride ()
GW791343 dihydrochloride ()
GW791343 (dihydrochloride) ()
GW 791343 ()
P&D ID
PD049417
CAS
1019779-04-4
309712-55-8
309712-73-0
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
GW791343 dihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC50 of 6.9-7.2. GW791343 dihydrochloride can enhance ATP rhythm. GW791343 dihydrochloride can be used in study of neurological disease[1][2].
PRICE
85
DESCRIPTION
GW791343 is an negative allosteric modulator of the human P2X7 receptor, but is a positive modulator of the rat orthologue . Mutational studies suggest that amino acid 95 is a key residue in determining the species difference in antagonist effects . The position 95 residue is phenylalanine in human P2X7 receptors, and leucine in rat.
(GtoPdb)
DESCRIPTION
GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.
(TargetMol Bioactive Compound Library)
DESCRIPTION
The hydrochlorie salt form of GW791343 that is a non-competitive inhibitor of human P2X7 receptors amd it seems to show species-specific activity which is probably negative allosteric modulators of the human P2X7 receptor and the agonist of the same recep
(BOC Sciences Bioactive Compounds)
DESCRIPTION
GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
GW791343, as a P2X7 receptor antagonist, was a negative allosteric modulator of the human P2X(7) receptor but at the rat P2X(7) receptor its predominant effect was positive allosteric modulation
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Guide to Pharmacology
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
374.19
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
2.73
TPSA
56.4
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
P2X Receptor
P2X7
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Solubility
DMSO: 42 mg/ml
Soluble in DMSO
Source data
