General
Preferred name
Patidegib
Synonyms
SARIDEGIB ()
Patidegib hydrochloride ()
IPI-926 ()
IP9 FREE BASE ()
Saridegib ()
FIN-5 ()
IP-9 ()
IPI-926 FREE BASE ()
IPI 926 ()
Saridegib hydrochloride ()
IPI-926 hydrochloride ()
P&D ID
PD049370
CAS
1037210-93-7
Tags
available
drug candidate
natural product
Drug indication
Chondrosarcoma
Basal cell carcinoma
Basal cell nevus syndrome
Drug Status
investigational
Max Phase
Phase 2
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Saridegib is an orally active inhibitor of the hedgehog signalling pathway, acting as an antagonist of the class frizzled GPCR, smoothened (SMO) .
(GtoPdb)
DESCRIPTION
Saridegib is an orally bioavailable, cyclopamine-derived inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity, one of smoothened (Smo) inhibitors.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
DrugBank
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
504.34
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
6
Aromatic Ring Count
0
cLogP
5.03
TPSA
67.43
Fraction CSP3
0.93
Chiral centers
11.0
Largest ring
7.0
QED
0.52
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Stem Cell/Wnt
Target
SMO
Source data