General
Preferred name
VU0119498
Synonyms
1-(4-Bromobenzyl)indole-2,3-dione ()
P&D ID
PD049347
CAS
79183-37-2
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION VU0119498 is a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM), with EC50s of 6.04, 6.38, and 4.08 ¦ÌM, respectively. VU0119498 has antidiabetic activity[1][2][3].
PRICE 29
DESCRIPTION VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 ??M) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.
DESCRIPTION 1-(4-Bromobenzyl)indole-2,3-dione is a pan Gq mAChR (muscarinic acetylcholine receptor) M1, M3, M5 positive allosteric modulator, with EC50s of 6, 6.4, and 4.1 µM, respectively. (Enamine Bioactive Compounds)
DESCRIPTION VU0119498 is an M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan-mAChR M3, M5 positive allosteric modulator (PAM), and a neuroprotective agent. It has anti-diabetic activity. (BOC Sciences Bioactive Compounds)
DESCRIPTION VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent. (TargetMol Bioactive Compound Library)
Compound Sets
9
BOC Sciences Bioactive Compounds
vu0119498-cas-79183-37-2-373057
Cayman Chemical Bioactives
36132
DrugMAP
DMPSI10
Enamine Bioactive Compounds
EBC-00587
Enamine BioReference Compounds
Guide to Pharmacology
7632
MedChem Express Bioactive Compound Library
HY-114933
Selleckchem Bioactive Compound Library
vu0119498
TargetMol Bioactive Compound Library
T8224
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
314.99
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
3.18
TPSA
37.38
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
mAChR
AChR
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Source data