General
Preferred name
PROXYFAN
Synonyms
Proxyfan oxalate ()
Proxyfan maleate ()
proxifan ()
P&D ID
PD049305
CAS
1620017-81-3
177708-09-7
Tags
drug candidate
biased GPCR ligand
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
High affinity H3 ligand
(Tocriscreen Plus)
DESCRIPTION
Proxyfan oxalate is a high affinity histamine H3 receptor ligand (pKi = 8.62), acting as a protean agonist with activity ranges from full agonist to inverse agonist depending on system used.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
High affinity H3 ligand
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
BiasDB
BOC Sciences Bioactive Compounds
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
216.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
2.56
TPSA
37.91
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
HRH3
MOA
histamine receptor modulator
Source data
