General
Preferred name
PD-168077
Synonyms
PD 168,077 maleate ()
PD 168077 maleate ()
PD-168077 maleate ()
PD168,077 ()
PD-168,077 ()
PD 168077 (maleate) ()
P&D ID
PD049297
CAS
630117-19-0
190383-31-4
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PD-168077 maleate is a selective dopamine D4 receptor agonist, with a Ki of 9 nM.
PRICE
68
DESCRIPTION
A3 selective agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective D4 dopamine receptor agonist
(LOPAC library)
DESCRIPTION
High affinity, selective D4 agonist
(Tocriscreen Total)
DESCRIPTION
PD 168077 maleate is a potent D4 dopamine receptor agonist (Ki = 8.7 nM) with > 400-fold selectivity over D2 and > 300-fold selectivity versus D3 subtypes respectively. It is suitable for central and peripheral delivery, and used in studies of penile erection, learning and memory.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
PD-168077 maleate is a selective agonist of the dopamine D4 receptor (Ki: 9 nM).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
334.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
2.38
TPSA
59.37
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.93
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D4
Target
dopamine
DRD2
Dopamine Receptor
Primary Target
D4 Receptors
MOA
Agonist
Dopamine Receptor agonist
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data
