General
Preferred name
URIDINE DIPHOSPHATE GLUCOSE
Synonyms
UDP-glucose ()
UDPG, UDP-Glc, UDP-D-Glucose disodium salt, UDP-¦Á-D-Glucose sodium salt ()
Uridine 5'-diphosphoglucose disodium salt ()
Uridine 5¡ä-diphosphoglucose (disodium salt) ()
UDP-Glucose (sodium salt hydrate) ()
UDP-D-Glucose (disodium salt) ()
UDP-alpha-D-Glucose ()
P&D ID
PD049275
CAS
28053-08-9
133-89-1
Tags
available
covalent binder
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Uridine 5¡¯-diphosphoglucose (UDP-glucose) disodium salt, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5¡¯-diphosphoglucose disodium salt is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5¡¯-diphosphoglucose disodium salt is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue[1][2][3][4].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugMAP
EUbOPEN Chemogenomics Library
Guide to Pharmacology
Selleckchem Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
61
Molecular Weight
566.06
Hydrogen Bond Acceptors
16
Hydrogen Bond Donors
9
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
1
cLogP
-4.79
TPSA
296.99
Fraction CSP3
0.73
Chiral centers
11.0
Largest ring
6.0
QED
0.13
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
P2 Receptor
Endogenous Metabolite
P2Y Receptor
Pathway
GPCR/G protein
Metabolic Enzyme/Protease
Recommended Cell Concentration
10 uM
Source data
