General
Preferred name
SB-269970
Synonyms
SB 269970 hydrochloride ()
SB269970 HCl ()
SB 269970-A ()
SB-269970 (hydrochloride) ()
SB-269970A ()
SB-269970 hydrochloride ()
[3H]SB269970 ()
P&D ID
PD049223
CAS
261901-57-9
201038-74-6
Tags
available
drug candidate
Drug indication
Discovery agent
Sleep-wake disorder
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Prostaglandin. Vasodilator and antiplatelet agent in vivo (Tocris Bioactive Compound Library)
DESCRIPTION Potent and selective 5-HT7 antagonist; brain penetrant (Tocriscreen Plus)
DESCRIPTION Selective 5-HT7 serotonin receptor antagonist (LOPAC library)
DESCRIPTION Potent selective 5-HT7 antagonist. Brain penetrant (Tocriscreen Total)
DESCRIPTION SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
21
AdooQ Bioactive Compound Library
A11925
Axon Medchem Screening Library
2183
BOC Sciences Bioactive Compounds
sb-269970-hydrochloride-cas-261901-57-9-368286
Cayman Chemical Bioactives
17081
Concise Guide to Pharmacology 2017/18
3233
3247
Concise Guide to Pharmacology 2019/20
3233
3247
Concise Guide to Pharmacology 2021/22
3233
3247
Concise Guide to Pharmacology 2023/24
3233
3247
Drug Repurposing Hub
DrugBank
DB13988
DrugMAP
DMFHUGC
DM8WTGA
EUbOPEN Chemogenomics Library
Guide to Pharmacology
3233
3247
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-7428203184
MedChem Express Bioactive Compound Library
HY-15370A
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
sb-269970-hcl
Tocris Bioactive Compound Library
1612
Tocriscreen Plus
1612
Tocriscreen Total
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
352.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
1
cLogP
2.67
TPSA
60.85
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
5-HT7
Target
5-HT Receptor
HTR7
5-HT7 antagonist
Pathway
Neuronal Signaling
GPCR/G protein
Primary Target
5-HT7 Receptors
MOA
Antagonist
5-HT7 Antagonists
serotonin receptor antagonist
Member status
member
Source data