General
Preferred name
AZ11645373
Synonyms
3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE ()
AZ 11645373 ()
P&D ID
PD049193
CAS
227088-94-0
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 221
DESCRIPTION AZ 11645373 (3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE) is a highly selective and potent human P2X7 receptor antagonist that has no effect on mouse/rat P2X7 receptor. (TargetMol Bioactive Compound Library)
DESCRIPTION Brain penetrant NMDA antagonist; acts at glycine site (Tocris Bioactive Compound Library)
Compound Sets
10
Concise Guide to Pharmacology 2017/18
4142
Concise Guide to Pharmacology 2019/20
4142
Concise Guide to Pharmacology 2021/22
4142
Concise Guide to Pharmacology 2023/24
4142
DrugMAP
DMDRXCP
EUbOPEN Chemogenomics Library
EUB0001966
Guide to Pharmacology
4142
MedChem Express Bioactive Compound Library
HY-108670
TargetMol Bioactive Compound Library
T21659
Tocris Bioactive Compound Library
3317
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
463.12
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
3
cLogP
4.73
TPSA
102.64
Fraction CSP3
0.21
Chiral centers
1.0
Largest ring
6.0
QED
0.33
QED
0.33
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
human P2X7
P2X Receptor
Primary Target
Purinergic (P2X) Receptors
MOA
Antagonist
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Recommended Cell Concentration
None
Source data