INDICATION In dermatology, topical clobestasone butyrate helps to reduce the itchiness and erythema associated with eczema and dermatitis.; In ophthalmology, clobetasone butyrate 0.1% eye drops have been shown to be safe and effective in the treatment of dry eyes in Sjögren's Syndrome.

ABSORPTION Absorption is dependent on many drug-related factors including: intrinsic properties of the steroid itself; concentration of the drug (increased concentration generally leads to more drug being absorbed but may plateau at higher concentrations); vehicle used (optimized or augmented vehicles > ointments or gels > creams or lotions); duration of exposure; frequency of application; combination with other products that break down the skin barrier and increase absorption (e.g., salicylic acid, urea). Patient-related factors that influence absorption include: patient age (infants and children absorb topical medications more quickly and to a greater degree than adults, and have a greater total skin surface to body weight ratio; the elderly have thinner skin and absorb drug more readily); disruption of the skin due to inflammation or disease (e.g., absorption increased in atopic dermatitis); total skin area treated; skin site treated (absorption is much greater from thin-skinned areas such as scalp, face, eyelid, axilla, and scrotum than from areas with thicker skin such as forearm, knee, elbow, palm and sole); absorption is increased with increased temperature or humidity of the skin or the environment; occlusion of the treated skin (via plastic wrap, oily vehicles, dressings, tape, diapers, tight-fitting clothing, etc.) can increase absorption up to 10-fold.;

TOXICITY Organism : Mouse; Test type: LD50 Oral (Reported dose: >6gm/kg); LD50 Subcutaneous ( >3600mg/kg ); Effects : Behavioral : somnolence ( general depressed activity ); Blood changes in spleen ; ; Organism : Mouse; Test type: LD50; Route: Intraperitoneal; Reported dose: 500 mg/kg; ; LD50 rat : 1510mg/kg Intraperitoneal; LD50 rat >6gm/kg Oral; LD 50 rat : > 2600mg/kg subcutaneous

DESCRIPTION Clobetasone is a corticosteroid used in dermatology. (GtoPdb)