General
Preferred name
CP 376395
Synonyms
CP 376395 hydrochloride ()
CP376395 ()
CP-316311 ()
CP-376395 ()
CP-376395 HCl ()
CP 376,395 ()
P&D ID
PD049099
CAS
175140-00-8
1013933-37-3
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
CP 376,395 (CP-376395) is an orally active, selective CRF1 receptor antagonist .
(GtoPdb)
DESCRIPTION
GABAB antagonist; displays activity at presynaptic receptors
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent and selective CRF1 antagonist
(Tocriscreen Plus)
DESCRIPTION
CP-376395 HCl is a potent and selective CRF1 receptor antagonist with Ki values of 12 and >10000 nM for CRF1 and CRF2 receptors respectively. It attenuates CRF-induced activation of the HPA axis in vivo.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
326.24
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
6.02
TPSA
34.15
Fraction CSP3
0.48
Chiral centers
0.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Pathway
GPCR/G protein
Target
CRF
CRHR1
CRFR
Primary Target
CRF1 Receptors
MOA
Antagonist
corticotropin releasing factor receptor antagonist
Solubility
Soluble to 50 mM in water and to 100 mM in DMSO
Source data
