General
Preferred name
JNJ-42165279
Synonyms
JNJ42165279 ()
Carbamide derivative 1 ()
JNJ-5279 ()
P&D ID
PD049087
CAS
1346528-50-4
Tags
available
drug candidate
Drug indication
Anxiety disorder
Social anxiety disorder
Autism spectrum disorder
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION JNJ-42165279 is an orally active FAAH inhibitor, with IC50 values of 70 nM for hFAAH and 313 nM for rFAAH. JNJ-42165279 can be used in research related to the field of neuropathic pain[1][2].
PRICE 77
DESCRIPTION JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 (10 ??M) exhibits high selectivity against a panel of 50 receptors, enzymes, transporters, and ion-channels, at which concentration it does not produce >50% inhibition of binding to any of the targets. Fortunately, JNJ-42165279 (10 ??M) also does not inhibit CYPs (1A2, 2C8, 2C9, 2C19, 2D6, 3A4) or hERG.
DESCRIPTION JNJ-42165279 is an investigational, covalent and selective inhibitor of fatty acid amide hydrolase (FAAH) . Preclinical test findings are reported in , with the conclusion that the favourable ADME and pharmacodynamic profiles of JNJ-42165279 supported it being progressed to clinical trial. (GtoPdb)
DESCRIPTION JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 (10 μM) exhibits high selectivity against a panel of 50 receptors, enzymes, transporters, and ion-channels, at which concentration it does not produce >50% inhibition of binding to any of the targets. Fortunately, JNJ-42165279 (10 μM) also does not inhibit CYPs (1A2, 2C8, 2C9, 2C19, 2D6, 3A4) or hERG. (TargetMol Bioactive Compound Library)
Compound Sets
13
Cayman Chemical Bioactives
19987
ChEMBL Drugs
CHEMBL4297294
Drug Repurposing Hub
DrugBank
DB15173
DrugMAP
DMXQTPJ
DM72GZO
EU-OPENSCREEN Bioactive Compound Library
EOS101784
Guide to Pharmacology
9012
Mcule NIBR MoA Box Subset
MCULE-4121409660
MedChem Express Bioactive Compound Library
HY-19636
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
jnj-42165279
TargetMol Bioactive Compound Library
T3215
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
410.1
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
2
cLogP
3.41
TPSA
66.93
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Autophagy
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Neuronal Signaling
Member status
member
MOA
FAAH inhibitor
Target
FAAH
hFAAH
rFAAH
Source data