General
Preferred name
VALBENAZINE
Synonyms
NBI-98854 ()
VALBENAZINE TOSYLATE ()
Ingrezza ()
Valbenazina ()
Mt-5199 ()
Valbenazine tosilate ()
Valbenazine ditosylate ()
P&D ID
PD049067
CAS
1025504-45-3
1639208-54-0
Tags
available
drug
prodrug
Approved by
FDA
PMDA
First approval
2017
Drug indication
Tardive dyskinesia
Tourette syndrome
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Valbenazine is an analogue of , which similarly selectively inhibits the monoamine transporter SLC18A2 (VMAT2). A search of patent literature reveals valbenazine as example 2-1 in US8357697 B2 .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
418.28
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
1
cLogP
3.56
TPSA
74.02
Fraction CSP3
0.71
Chiral centers
4.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Target
VMAT2
Monoamine transporter
VMAT
Indication
dyskinesia
MOA
vesicular monoamine transporter inhibitor
Source data
