General
Preferred name
JNJ-10311795
Synonyms
RWJ-355871 ()
RWJ355871 ()
JNJ10311795 ()
P&D ID
PD049008
CAS
518062-14-1
Tags
available
drug candidate
Drug indication
Chronic obstructive pulmonary disease
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
1108
DESCRIPTION
JNJ-10311795 is a chymase inhibitor with cathepsin G cross-reactivity. The isomer in CID 656932 is contained in PDB X-ray crystal structures . It is suggested to have potential clinical utility in pulmonary inflammatory diseases such as asthma and COPD.
(GtoPdb)
DESCRIPTION
JNJ10311795 is a dual inhibitor of Chymase and leukocyte Proteases Cathepsin G. It has inflammation therapeutic efficacy in animals models.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
JNJ-10311795 (RWJ-355871) is a potent dual inhibitor of neutrophil elastase (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM) with significant anti-inflammatory activity, useful for studying pneumonia.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
BOC Sciences Bioactive Compounds
DrugMAP
Guide to Pharmacology
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
16
Molecular Weight
670.22
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
7
Aromatic Ring Count
6
cLogP
7.62
TPSA
115.22
Fraction CSP3
0.17
Chiral centers
1.0
Largest ring
6.0
QED
0.13
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Cathepsin
Pathway
Proteases/Proteasome
Solubility
Soluble in DMSO, not in water
Source data
