General
Preferred name
ZM-39923
Synonyms
ZM 39923 hydrochloride ()
JAK3 inhibitor IV ()
ZM 39923 HCl ()
ZM39923 (hydrochloride) ()
ZM39923 hydrochloride ()
ZM 39923 (hydrochloride) ()
P&D ID
PD048975
CAS
1021868-92-7
58753-54-1
273727-89-2
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 hydrochloride also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.
PRICE
73
DESCRIPTION
This is compound 7 in .
DESCRIPTION
This is compound 7 in , and is also known as ZM39923. It was originally identified as an ATP-binding site inhibitor of JAK3 , but has additionally been reported to inhibit transglutaminase 2 (TGM2) with nanomolar potency in vitro .
(GtoPdb)
DESCRIPTION
GCP II inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Janus kinase 3 (JNK-3) inhibitor.
(LOPAC library)
DESCRIPTION
Potent, selective JAK3 inhibitor
(Tocriscreen Total)
DESCRIPTION
ZM 39923 hydrochloride is a potent and selective inhibitor of Janus tyrosine kinase 3 (JAK3) (pIC50 = 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4, respectively). ZM 39923 breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25°C) to produce an active analog, ZM 449829.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
ZM 39923 HCl is a potent and selective inhibitor of JAK3, and also inhibits EGFR, JAK1 and CDK4. It breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25°C) to form ZM 449829.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Potent, selective JAK3 inhibitor
(Tocriscreen Plus)
DESCRIPTION
ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
15
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
331.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
5.32
TPSA
20.31
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Selectivity
JNK-3
Target
JAK
EGFR
JAK1
JAK3
TGM2
JAK1, JAK3
Pathway
Epigenetics
Stem Cell/Wnt
JAK/STAT Signaling
Protein Tyrosine Kinase/RTK
Angiogenesis
Chromatin/Epigenetic
Stem Cells
Tyrosine Kinase/Adaptors
Primary Target
JAK Kinase
MOA
Others inhibitor
Inhibitor
JAK inhibitor
Source data
