General
Preferred name
IMMEPIP
Synonyms
Immepip dihydrobromide ()
Immepip (dihydrobromide) ()
Immepip (hydrobromide) ()
P&D ID
PD048960
CAS
164391-47-3
151070-83-6
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Immepip (dihydrobromide) is used as a standard H3 receptor agonist; also H4 agonist.
(GtoPdb)
DESCRIPTION
D2-like antagonist; also high affinity 5-HT7 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Standard H3 agonist. Also H4 agonist
(Tocriscreen Total)
DESCRIPTION
Immepip dihydrobromide is the dihydrobromide salt of immepip, which is a potent and selective nonchiral histamine H3 receptor agonist with Ki values of 0.4 nM. It is selective equipotent to (R)-α-methylhistamine and is effective in vitro and in vivo. It is devoid of side activities elicited at H1, α2 receptors and 5-HT3 receptors.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugMAP
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
165.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
0.95
TPSA
40.71
Fraction CSP3
0.67
Chiral centers
0.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Histamine H3 Receptors
MOA
Agonist
Histamine Receptor agonist
Target
HRH3, HRH4
H3/H4 agonist
ITK
Pathway
Protein Tyrosine Kinase/RTK
Source data
