General
Preferred name
NO-711
Synonyms
NNC 711 ()
NO-711 hydrochloride ()
E-6276 ()
NNC-711 ()
NO-711 (hydrochloride) ()
NNC-711 (hydrochloride) ()
NNC 05-711 ()
NO 711 ()
P&D ID
PD048959
CAS
145645-62-1
159094-94-7
Tags
available
drug candidate
Drug indication
Discovery agent
Schizophrenia
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
211
DESCRIPTION
NNC 05-711 (NO-711 hydrochloride) is a potent and selective inhibitor of GAT-1 (GABA transporter 1), which inhibits GABA reuptake and thereby increases GABA levels in the synaptic gap, exerting anticonvulsant and analgesic effects.
PRICE
828
DESCRIPTION
NO 711??NNC-711 free acid?? is a potent and selective inhibitor of GABA transporter 1 (GAT-1), which increases GABAergic transmission, enhances non-rapid eye movement sleep, and prevents and treats paclitaxel-induced neuropathic pain.
DESCRIPTION
Selective facilitator of 5-HT uptake; antidepressant
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective inhibitor of GAT-1
(Tocriscreen Plus)
DESCRIPTION
Potent and selective GABA uptake inhibitor.
(LOPAC library)
DESCRIPTION
Selective inhibitor of GAT-1
(Tocriscreen Total)
DESCRIPTION
NNC 711 is a GABA uptake inhibitor by GAT-1 with IC50 values of 0.04, 171, 1700 and 622 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1. NNC 711 is an anticonvulsantagent.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMatrix
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
350.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
3.17
TPSA
62.13
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Transporters
Selectivity
Uptake
Primary Target
GABA Transporters
MOA
Inhibitor
GAT-1 Inhibitors
GABA uptake inhibitor
Member status
member
Target
SIGMAR1, SLC6A1
GABA Receptor
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Recommended Cell Concentration
None
Source data
