General
Preferred name
CIPROXIFAN
Synonyms
Ciproxifan hydrochloride ()
FUB-359 ()
FUB 359 maleate ()
FUB 359 ()
Ciproxifan maleate ()
Ciproxifan (maleate) ()
P&D ID
PD048935
CAS
184025-19-2
184025-18-1
Tags
available
drug candidate
Drug indication
Obesity
Dementia
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION H3 Histamine receptor antagonist (LOPAC library)
DESCRIPTION Ciproxifan is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
3
Compound Sets
17
AdooQ Bioactive Compound Library
A11117
Axon Medchem Screening Library
1993
BOC Sciences Bioactive Compounds
ciproxifan-cas-184025-18-1-item-84-425084
Cayman Chemical Bioactives
29513
Concise Guide to Pharmacology 2017/18
1265
Concise Guide to Pharmacology 2019/20
1265
Concise Guide to Pharmacology 2021/22
1265
Concise Guide to Pharmacology 2023/24
1265
Drug Repurposing Hub
DrugMAP
DM9N8WM
EU-OPENSCREEN Bioactive Compound Library
EOS101067
Guide to Pharmacology
1265
LOPAC library
MedChem Express Bioactive Compound Library
HY-15289
Other bioactive compounds
Selleckchem Bioactive Compound Library
ciproxifan
TargetMol Bioactive Compound Library
T2004
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
270.14
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
3.01
TPSA
54.98
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H3
Target
Histamine Receptor
H3 receptor
ADRA2A, ADRA2C, HRH3, HRH4, HTR3A
H3 antagonist
Pathway
Neuronal Signaling
GPCR/G protein
Immunology/Inflammation
Neuroscience
MOA
Histamine Receptor antagonist
Source data