General
Preferred name
fosbretabulin
Synonyms
Combretastatin A4 Phosphate ()
CA 4DP ()
CA 4P ()
Combretastatin A4 disodium phosphate ()
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium ()
Fosbretabulin disodium (CA4P) ()
fosbretabulin tromethamine ()
Fosbretabulin (disodium) ()
FOSBRETABULIN DISODIUM ()
Combrestatin A4 3'-O-Phosphate (sodium salt) ()
CA-4DP ()
CA4DP ()
Fosbretabulin disodium salt ()
Fosbretabulina ()
Phosbretabulin ()
Fosbretabuline ()
Combretastatin a-4 phosphate ()
Zybrestat ()
P&D ID
PD048804
CAS
222030-63-9
168555-66-6
Tags
available
prodrug
drug candidate
Drug Status
investigational
Max Phase
2.0
3.0
Drug indication
neuroendocrine neoplasm
Neoplasm
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
91
DESCRIPTION
Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds ??-tubulin (Kd: 0.4 ??M). Fosbretabulin Disodium(Combretastatin A4 disodium phosphate) inhibits the polymerization of tubulin (IC50: 2.4 ??M), and also disrupts tumor vasculature.
DESCRIPTION
Fosbretabulin is being investigated for anti-tumour potential. It interferes with vascularisation by preventing tubulin-polymerisation and disrupting cell junctions . This action destroys tumour vasculature and leads to cancer cell death and necrosis. Mechanistically, fosbretabulin is dephosphorylated to the active tubulin polymerisation inhibitor . The compound was originally isolated from the African bush willow (Combretum caffrum) .
(GtoPdb)
DESCRIPTION
Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). Fosbretabulin Disodium(Combretastatin A4 disodium phosphate) inhibits the polymerization of tubulin (IC50: 2.4 μM), and also disrupts tumor vasculature.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
24
Organisms
1
Compound Sets
11
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
51
Molecular Weight
396.1
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
3.36
TPSA
103.68
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Microtubule/Tubulin
Tubulin
CDH5
Apoptosis related,Microtubule Associated
MOA
Microtubule Associated inhibitor
tubulin polymerization inhibitor, VE-cadherin antagonist
Pathway
Cytoskeletal Signaling
Cell Cycle/DNA Damage
cytoskeleton
Source data
