General
Preferred name
thiochrome
Synonyms
P&D ID
PD048753
CAS
51810-67-4
92-35-3
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors[1][2].
Compound Sets
7
Concise Guide to Pharmacology 2017/18
348
Concise Guide to Pharmacology 2019/20
348
Concise Guide to Pharmacology 2021/22
348
Concise Guide to Pharmacology 2023/24
348
DrugMAP
DML4TQ5
Guide to Pharmacology
348
MedChem Express Bioactive Compound Library
HY-N7247
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
262.09
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
1
cLogP
1.95
TPSA
61.61
Fraction CSP3
0.42
Chiral centers
0.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
mAChR
Pathway
GPCR/G protein
Neuronal Signaling
Source data