General
Preferred name
L-750,667
Synonyms
L-750,667 trihydrochloride ()
L750,667 Trihydrochloride ()
L-750667 triHydrochloride ()
[125I]L750667 ()
L-750667 (triHydrochloride) ()
L-750667 ()
[125I]L750667 ()
P&D ID
PD048725
CAS
1021868-80-3
158985-08-1
Tags
drug candidate
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
L-750667 triHydrochloride is a selective antagonist for the D4 dopamine receptor, with a Ki value of 0.51 nM. The radiolabeled form of L-750667, [125I]L-750,667, has a Kd value of 0.16 nM for the D4 receptor. L-750667 triHydrochloride can reverse dopamine-induced inhibition of cAMP accumulation. It can be used to study the distribution and function of D4 dopamine receptors in the central nervous system and has potential applications in the fields of neuroscience and psychiatry[1][2].
PRICE
215
DESCRIPTION
Selective D4 dopamine receptor antagonist
(LOPAC library)
DESCRIPTION
L-750,667 Trihydrochloride is a selective D4 dopamine receptor antagonist with high potency (Ki = 0.51 nM). By reversing the dopamine-induced inhibition of cAMP (cyclic adenosine monophosphate) accumulation, L-750667 trihydrochloride can be used to study D4 receptors in the central nervous system.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
9
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
LOPAC library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
418.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
3.49
TPSA
35.16
Fraction CSP3
0.28
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Dopamine Receptor
HSP70
Selectivity
D4
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data
