General
Preferred name
SEGLITIDE
Synonyms
MK 678 ()
MK678 ()
MK-678 ()
Seglitide (acetate) ()
MK 678 (acetate) ()
L 36358 (acetate) ()
L-363586 ()
SEGLITIDE ACETATE ()
Seglitida ()
P&D ID
PD048696
CAS
99248-33-6
81377-02-8
Tags
available
drug candidate
Drug indication
Pain
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION A cyclic peptide (GtoPdb)
DESCRIPTION Seglitide (MK-678) is a potent, orally active somatostatin receptor 2 (SSTR2) agonist, and also a competitive antagonist of SSTR14, SSTR25, and SSTR28. Seglitide has antihypertensive effects and can inhibit plasma glucagon and growth hormone. Seglitide can be used for research on diabetes[1][2][3].
DESCRIPTION Seglitide acetate (MK 678; L 36358 acetate) is a potent, orally active somatostatin receptor 2 (SSTR2) agonist, and also a competitive antagonist of SSTR14, SSTR25, and SSTR28. Seglitide acetate has antihypertensive effects and can inhibit plasma glucagon and growth hormone. Seglitide acetate can be used for research on diabetes[1][2][3].
DESCRIPTION Seglitide is a selective sst2 and sst5 somatostatin receptor agonist. (BOC Sciences Bioactive Compounds)
DESCRIPTION Seglitide acetate (MK-678) is a selective agonist of sst2 somatostatin receptor. (TargetMol Bioactive Compound Library)
Compound Sets
9
BOC Sciences Bioactive Compounds
seglitide-cas-81377-02-8-item-34065
Cayman Chemical Bioactives
42497
ChEMBL Drugs
CHEMBL311695
CHEMBL2103887
DrugMAP
DMXZVPH
Guide to Pharmacology
2051
MedChem Express Bioactive Compound Library
HY-106103
HY-106103A
ReFrame library
TargetMol Bioactive Compound Library
T28743
ZINC Tool Compounds
ZINC000085537084
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
808.43
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
8
Rotatable Bonds
11
Ring Count
5
Aromatic Ring Count
4
cLogP
1.97
TPSA
227.85
Fraction CSP3
0.41
Chiral centers
6.0
Largest ring
18.0
QED
0.1
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
SST2
Somatostatin Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Source data