General
Preferred name
NEUROTENSIN
Synonyms
NEUROTENSIN TFA ()
Neurotensin TFA (39379-15-2 free base) ()
Neurotensin (trifluoroacetate salt) ()
[3H]neurotensin (human, mouse, rat) ()
P&D ID
PD048655
CAS
39379-15-2
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Neurotensin TFA (39379-15-2 free base) is an endogenous 13 amino acid neuropeptide with profound opioid-independent analgesic effects. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a neuromodulator. It is implicated in the pathophysiology of several CNS disorders (including schizophrenia, Parkinson's disease, drug abuse, pain, cancer, inflammation, eating disorders, and central control of blood pressure) due to its association with a wide variety of neurotransmitter systems such as dopaminergic, sertonergic, glutamatergic, GABAergic, and cholinergic systems. It has a role as a human metabolite, a mitogen, a neurotransmitter and a vulnerary.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
1671.91
Hydrogen Bond Acceptors
21
Hydrogen Bond Donors
21
Rotatable Bonds
50
Ring Count
5
Aromatic Ring Count
2
cLogP
-3.81
TPSA
673.69
Fraction CSP3
0.62
Chiral centers
14.0
Largest ring
6.0
QED
0.02
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
GABA Receptor
Neurotensin Receptor
Pathway
Membrane Transporter/Ion Channel
Neuroscience
GPCR/G protein
Neuronal Signaling
Source data
