General
Preferred name
taurocholic acid
Synonyms
N-Choloyltaurine ()
Sodium taurocholate ()
Taurocholic acid (sodium salt hydrate) ()
Taurocholic acid (sodium) ()
Sodium Taurocholate hydrate ()
N-Choloyltaurine (sodium salt hydrate) ()
N-Choloyltaurine (sodium) ()
Sodium Taurocholate, TANa ()
Taurocholic acid sodium salt ()
Taurocholic Acid (sodium salt) ()
Taurocholic Acid-d4 (sodium salt) ()
Cholaic acid ()
Cholic acid taurine conjugate ()
Taurocholic Acid-d4 MaxSpec® Standard ()
Taurocholic Acid MaxSpec® Standard ()
Taurocholic acid sodium salt hydrate ()
P&D ID
PD048547
CAS
113341-22-3
145-42-6
81-24-3
345909-26-4
2410279-93-3
252030-90-3
Tags
available
drug candidate
drug
Drug indication
Type-2 diabetes
Drug Status
approved
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Taurocholic acid sodium salt hydrate (Sodium taurocholate hydrate) is a bile acid involved in the emulsification of fats.
PRICE 29
DESCRIPTION Taurocholic acid sodium salt hydrate (Sodium taurocholate hydrate), formed by the conjugation of taurine with cholic acid, is the primary ingredient in the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is employed as a cholagogue and choleretic.
DESCRIPTION Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect[1].
DESCRIPTION Taurocholic acid (N-Choloyltaurine) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid has immunoregulation effect[1].
PRICE 82
DESCRIPTION Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-alpha-induced cholangiocyte damage via a PI3K-mediated pathway. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
14
Cayman Chemical Bioactives
16215
31374
21891
31375
Concise Guide to Pharmacology 2017/18
4546
4547
Concise Guide to Pharmacology 2019/20
4546
4547
Concise Guide to Pharmacology 2021/22
4546
4547
Concise Guide to Pharmacology 2023/24
4546
4547
Drug Repurposing Hub
DrugBank
DB04348
DrugBank Approved Drugs
DB04348
DrugMAP
DM3GO0J
DM2LZ8F
Guide to Pharmacology
4546
4547
MedChem Express Bioactive Compound Library
HY-B1131
HY-N0545
HY-B1788
ReFrame library
Selleckchem Bioactive Compound Library
taurocholic-acid-sodium-salt
TargetMol Bioactive Compound Library
TN2259
External IDs
108
Properties
(calculated by RDKit )
Molecular Weight
515.29
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
5
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
0
cLogP
2.37
TPSA
144.16
Fraction CSP3
0.96
Chiral centers
11.0
Largest ring
6.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PI3K
TNF-α
CEL, FABP6, SLCO1C1
Endogenous Metabolite
VEGFR
MOA
G protein-coupled receptor agonist
Pathway
Apoptosis
PI3K/Akt/mTOR signaling
Metabolic Enzyme/Protease
Protein Tyrosine Kinase/RTK
Source data