General
Preferred name
vesamicol
Synonyms
VESAMICOL HYDROCHLORIDE ()
(±)-Vesamicol hydrochloride ()
(±)-AH5183 hydrochloride ()
WAY-221060-A ()
[3H]vesamicol ()
[3H]vesamicol ()
P&D ID
PD048546
CAS
22232-64-0
23965-53-9
120447-62-3
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
56
DESCRIPTION
Vesamicol hydrochloride ((??)-AH5183 hydrochloride) is a acetylcholine transport inhibitor.
DESCRIPTION
Potent inhibitor of vesicular acetylcholine storage
(LOPAC library)
DESCRIPTION
(±)-Vesamicol hydrochloride is an inhibitor of acetylcholine transport (Ki = 2 nM) that blocks the loading of acetylcholine into synaptic vesicles of cholinergic nerve terminals. The inhibition by Vesamicol attenuates acetylcholine neuronal signaling without direct effecys on signaling mechanisms.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a acetylcholine transport inhibitor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
BOC Sciences Bioactive Compounds
CZ-OPENSCREEN Bioactive Library
EU-OPENSCREEN Bioactive Compound Library
LOPAC library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
259.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
1
cLogP
3.17
TPSA
23.47
Fraction CSP3
0.65
Chiral centers
2.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
ACh storage
Target
AChR
Pathway
Neuroscience
Source data
