General
Preferred name
Uridine-5'-Diphosphate
Synonyms
Uridine 5'-diphosphate sodium ()
URIDINE_DIPHOSPHATE ()
UDP disodium salt ()
Uridine-5'-diphosphate disodium salt ()
UDP (sodium salt hydrate) ()
UDP ()
P&D ID
PD048470
CAS
27821-45-0
58-98-0
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
High affinity, potent CCR2 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
P2Y receptor agonist
(LOPAC library)
DESCRIPTION
Uridine-5'-diphosphate disodium salt (UDP disodium salt) is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstriction. Uridine-5'-diphosphate disodium salt also acts as an antagonist of P2Y14.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugMAP
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
63
Molecular Weight
404.0
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
6
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
-2.62
TPSA
217.84
Fraction CSP3
0.56
Chiral centers
5.0
Largest ring
6.0
QED
0.27
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
P2Y
Target
DNA/RNA Synthesis
Endogenous Metabolite
P2Y14
P2Y6
P2Y Receptor
P2 Receptor
Primary Target
Purinergic (P2Y) Receptors
Member status
virtual
MOA
P2Y6 purinoceptor antagonist
Pathway
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
GPCR/G protein
Metabolism
Neuroscience
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Recommended Cell Concentration
1 uM
Source data
