General
Preferred name
WAY-181187
Synonyms
WAY 181187 ()
WAY181187 ()
WAY 181187 oxalate ()
SAX-187 ()
P&D ID
PD048404
CAS
1883548-85-3
554403-49-5
Tags
available
drug candidate
Drug indication
Anxiety disorder
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
220
DESCRIPTION
WAY181187 is a potent and selective 5-HT6 receptor full agonist. It possesses high affinity binding at the human 5-HT6 receptor and profile as full receptor agonists. It induces robust increases in extracellular GABA levels in the frontal cortex, striatum, hippocampus and amygdala of rats. It has modest to no effects on norepinephrine, serotonin, dopamine, or glutamate levels. It has demonstrated preclinical efficacy in rodent models of depression, anxiety, and notably obsessive-compulsive disorder.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
SAX-187 (SAX-187) has high-affinity binding at the human 5-HT6 receptor.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Potent and selective mGlu5 antagonist; brain penetrant
(Tocris Bioactive Compound Library)
DESCRIPTION
WAY 181187 oxalate is a selective and high affinity 5-HT6 agonist with 60-fold selectivity over other 5-HT and monoamine receptors.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
EUbOPEN Chemogenomics Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
380.02
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
4
cLogP
2.74
TPSA
82.39
Fraction CSP3
0.13
Chiral centers
0.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT Receptor
5-HT6
Primary Target
5-HT6 Receptors
MOA
Agonist
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Solubility
Soluble in DMSO, not in water
Recommended Cell Concentration
100 nM
Source data
