General
Preferred name
ADP-597
Synonyms
JNJ-38431055 ()
APD597 ()
APD 597 ()
APD-597 ()
Jnj-38431055 ()
P&D ID
PD048349
CAS
897732-93-3
Tags
available
drug candidate
Drug indication
Type-2 diabetes
type 2 diabetes mellitus
Drug Status
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119.;IC50 value: 46 nM (EC50) [1];Target: hGPR119;The design and synthesis of a second generation GPR119-agonist clinical candidate for the treatment of diabetes is described. APD597 was selected for preclinical development based on a good balance between agonist potency, intrinsic activity and in particular on its good solubility and reduced drug-drug interaction potential. [1]
PRICE 108
DESCRIPTION JNJ-38431055 is a GPR119 receptor agonist. (GtoPdb)
DESCRIPTION APD597 (JNJ-38431055) is a GPR119 agonist, used in the treatment of type 2 diabetes. (TargetMol Bioactive Compound Library)
Compound Sets
15
AdooQ Bioactive Compound Library
A15452
Axon Medchem Screening Library
2541
Cayman Chemical Bioactives
22950
ChEMBL Drugs
CHEMBL1951032
Drug Repurposing Hub
DrugBank
DB12084
DrugMAP
DM36FOG
EU-OPENSCREEN Bioactive Compound Library
EOS101426
EUbOPEN Chemogenomics Library
EUB0000826
Guide to Pharmacology
5727
MedChem Express Bioactive Compound Library
HY-15566
ReFrame library
Selleckchem Bioactive Compound Library
apd597
TargetMol Bioactive Compound Library
T3176
ZINC Tool Compounds
ZINC000038256220
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
479.18
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
2.72
TPSA
132.84
Fraction CSP3
0.52
Chiral centers
0.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
GPR119
GPR119 agonist
GPR,P450 (e.g. CYP17)
MOA
glucose dependent insulinotropic receptor agonist
Pathway
GPCR/G protein
Neuronal Signaling
Endocrinology/Hormones
Recommended Cell Concentration
1 uM
Source data