General
Preferred name
DG-041
Synonyms
DG 041 ()
DG041 ()
P&D ID
PD048339
CAS
861238-35-9
Tags
available
drug candidate
Drug indication
Peripheral vascular disease
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
DG-041 is a potent, high affinity and selective EP3 receptor antagonist with IC50s of 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively. DG-041 inhibits PGE2 facilitation of platelet aggregation. DG-041 crosses the blood-brain barrier[1][2].
PRICE
180
DESCRIPTION
Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
DG 041 inhibits PGE2 facilitation of platelet aggregation in vitro and ex vivo. Displays good plasma and metabolic stability.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
DG-041 is an antagonist of high affinity EP3 receptor (IC50s: 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively ). DG-041 inhibits PGE2 facilitation of platelet aggregation and it also crosses the blood-brain barrier.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
589.93
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
4
cLogP
7.33
TPSA
68.17
Fraction CSP3
0.09
Chiral centers
0.0
Largest ring
6.0
QED
0.24
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
EP3
Prostaglandin Receptor
Primary Target
Prostanoid Receptors
MOA
Antagonist
Pathway
GPCR/G protein
Immunology/Inflammation
Source data
