General
Preferred name
BMY-14802
Synonyms
BMY 14802 hydrochloride ()
BMS 181100 hydrochloride ()
BMY-14802-1 ()
alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol ()
BMS-181100 ()
BMY-14802 (hydrochloride) ()
BMY 14802 ()
BMS 181100 (hydrochloride) ()
BMY-14802 hydrochloride ()
BMY 14802 (hydrochloride) ()
P&D ID
PD048325
CAS
105565-55-7
105565-56-8
Tags
available
drug candidate
Drug indication
Psychotic disorder
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic ¦Á1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects[1][2][3].
PRICE
56
DESCRIPTION
BMY-14802 hydrochloride (BMS 181100 hydrochloride) is a selective antagonist of ?? receptor (IC50 = 112 nM) with antipsychotic effects. BMY-14802 hydrochloride is an agonist of the ??1-adrenergic receptor and 5-HT1A.
DESCRIPTION
BMY 14802 is a sigma-1 receptor (¦Ò1R) antagonist, as well as an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. BMY 14802 inhibits abnormal involuntary movement (AIM) in rat Parkinson's disease (PD) model, with down-regulating the expression of AIM[1][2].
PRICE
103
DESCRIPTION
sigma2 antagonist. Also DAT inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Sigma antagonist. Antipsychotic agent
(Tocriscreen Total)
DESCRIPTION
BMY 14802 hydrochloride is a potent sigma receptor antagonist (IC50 = 112 nM) with weak affinity for 5-HT1A and α1 receptors. BMY 14802 is potentially used as an atypical antipsychotic agent for schizophrenia treatment.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
BMY-14802 hydrochloride (BMS 181100 hydrochloride) is a selective antagonist of σ receptor (IC50 = 112 nM) with antipsychotic effects. BMY-14802 hydrochloride is an agonist of the α1-adrenergic receptor and 5-HT1A.
(TargetMol Bioactive Compound Library)
DESCRIPTION
BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
11
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugMAP
DrugMatrix
Guide to Pharmacology
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
348.18
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
2.39
TPSA
52.49
Fraction CSP3
0.44
Chiral centers
1.0
Largest ring
6.0
QED
0.87
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
σ
α1-adrenergic receptor
5-HT1A
Sigma Receptor
5-HT Receptor
Adrenergic Receptor
Primary Target
Sigma-Related
MOA
Antagonist
NMDA Antagonists
sigma Receptor Antagonists
"NMDA Antagonists
sigma Receptor Antagonists"
Member status
member
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Source data
