General
Preferred name
TAUROLITHOCHOLIC ACID
Synonyms
Sodium taurolithocholate ()
Taurolithocholic Acid (sodium salt) ()
Taurolithocholic acid sodium salt ()
taurolithocholic acid-3-sulphate ()
Taurolithocholate ()
Taurolithocholic Acid MaxSpec® Standard ()
Taurolithocholic Acid-d4 (sodium salt) ()
Taurolithocholic Acid-d4 MaxSpec® Standard ()
P&D ID
PD048320
CAS
516-90-5
6042-32-6
2410279-97-7
2410279-96-6
Tags
available
drug candidate
Drug Status
investigational
Max Phase
3.0
Drug indication
Primary biliary cirrhosis
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1].
PRICE
47
DESCRIPTION
Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but not to M2 or M3 receptors.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Other bioactive compounds
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
52
Molecular Weight
483.3
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
0
cLogP
4.43
TPSA
103.7
Fraction CSP3
0.96
Chiral centers
9.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Calcium Channel
Ca2+
Endogenous Metabolite
Pathway
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Neuronal Signaling
Metabolism
Source data
