General
Preferred name
OXOTREMORINE
Synonyms
OXOTREMORINE SESQUIFUMARATE ()
OXOTREMORINE SESQUIFUMARATE SALT ()
Green tea ()
Oxotremorine (sesquifumarate) ()
But-2-enedioic acid ()
1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidin-2-one ()
P&D ID
PD048315
CAS
17360-35-9
70-22-4
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Group III and group II mGlu antagonist; more selective for group III than group II
(Tocris Bioactive Compound Library)
DESCRIPTION
Muscarinic acetylcholine receptor agonist with preference for the M2 receptor
(LOPAC library)
DESCRIPTION
Muscarinic agonist
(Tocriscreen Total)
DESCRIPTION
Muscarinic agonist
(Tocriscreen Plus)
DESCRIPTION
A derivative of Oxotremorine. Oxotremorine is a selective muscarinic acetylcholine receptor agonist. It can be used as a parasympathomimetic drug.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
18
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DrugMatrix
Guide to Pharmacology
Ki Database
LOPAC library
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
206.14
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
0
cLogP
0.71
TPSA
23.55
Fraction CSP3
0.75
Chiral centers
0.0
Largest ring
5.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
M2
Primary Target
Non-selective Muscarinics
MOA
Agonist
Muscarinic receptor agonist
cholinergic receptor agonist
Member status
member
Target
CHRM1, CHRM2, CHRM3, CHRM4
mAChR
Pathway
GPCR/G protein
Neuronal Signaling
Source data
