General
Preferred name
FL118
Synonyms
FL 118 ()
FL-118 ()
10,11-(Methylenedioxy)-20(S)-camptothecin ()
compound 5z [PMID: 8410981] ()
P&D ID
PD048198
CAS
135415-73-5
104155-89-7
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 179
DESCRIPTION FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits epithelial-mesenchymal transition through the Wnt/??-catenin signaling pathway, thereby inhibiting migration and invasion of human breast cancer cells.
DESCRIPTION Compound 5z is an analogue of the natural alkaloid camptothecin (PubChem CID 24360) . (GtoPdb)
DESCRIPTION FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway, thereby inhibiting migration and invasion of human breast cancer cells. (TargetMol Bioactive Compound Library)
Cell lines
18
Organisms
0
Compound Sets
3
Guide to Pharmacology
8893
MedChem Express Bioactive Compound Library
HY-12486
TargetMol Bioactive Compound Library
T77701
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
392.1
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
6
Aromatic Ring Count
3
cLogP
1.81
TPSA
99.88
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Survivin
Apoptosis
IAP
Source data