General
Preferred name
LP-12
Synonyms
4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide ()
LP 12 hydrochloride ()
P&D ID
PD048172
CAS
1185136-22-4
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
LP-12 is a selective serotonin 5-HT7 receptor agonist .
(GtoPdb)
DESCRIPTION
LP 12 hydrochloride is a 5-HT7 receptor agonist. It can induce relaxation of substance P-induced contractions in guinea pig ileum with EC50 value of 1.77 μM.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
BOC Sciences Bioactive Compounds
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
Guide to Pharmacology
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
481.31
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
5
Aromatic Ring Count
3
cLogP
6.23
TPSA
35.58
Fraction CSP3
0.41
Chiral centers
1.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
