General
Preferred name
AF-DX 384
Synonyms
AF-DX-384 ()
AFDX384 ()
P&D ID
PD048138
CAS
118290-26-9
118290-27-0
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent and selective D3 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
AF-DX 384 has been found to be a mAChR M2/M4 selective antagonist.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugMAP
Ki Database
Mcule NIBR MoA Box Subset
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
478.31
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
2
cLogP
4.47
TPSA
80.81
Fraction CSP3
0.52
Chiral centers
1.0
Largest ring
7.0
QED
0.56
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Primary Target
M2 Receptors
MOA
Antagonist
dual CHRM2/CHRM4 antagonist
Member status
member
Source data