General
Preferred name
AZD5672
Synonyms
AZD-5672 ()
Azd 5672 ()
P&D ID
PD048113
Tags
available
drug candidate
Drug indication
Rheumatoid arthritis
Drug Status
investigational
Max Phase
Phase 2
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AZD5672 was an investigational small molecule antagonist of the C-C chemokine receptor type 5 (CCR5) expressed on T cells. AZD5672-induced CCR5 blockade was investigated for action in treating rheumatoid arthritis, but with discouraging clinical trial results. Other CCR5 antagonists ( and ) have also proven ineffective in RA clinical trials

The structure shown here was drawn from . (GtoPdb)
Compound Sets
5
ChEMBL Drugs
CHEMBL1951914
DrugMAP
DMQUX28
Guide to Pharmacology
7686
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1951914
ReFrame library
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
639.26
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
11
Ring Count
4
Aromatic Ring Count
2
cLogP
4.07
TPSA
95.07
Fraction CSP3
0.58
Chiral centers
1.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data