General
Preferred name
Ro0711401
Synonyms
RO-0711401 ()
Ro 0711401 ()
P&D ID
PD048061
CAS
714971-87-6
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM[1][2].
PRICE 56
DESCRIPTION Ro0711401 is an agonist of mGlu1 receptor. (TargetMol Bioactive Compound Library)
Compound Sets
5
Axon Medchem Screening Library
3422
DrugMAP
DMZLUAK
Guide to Pharmacology
6204
MedChem Express Bioactive Compound Library
HY-124419
TargetMol Bioactive Compound Library
T9021
External IDs
10
Properties
(calculated by RDKit )
Molecular Weight
360.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
3
cLogP
4.57
TPSA
64.36
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
mGluR
mGluR1
mGluR1 PAM
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Source data