General
Preferred name
monomethyl fumarate
Synonyms
monomethylfumarate ()
MMF ()
mono methyl fumarate ()
MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate ()
NSC-523835 ()
Fumaric acid monomethyl ester ()
Bafiertam ()
Fumarato de monometilo ()
Fumarate de monomethyle ()
P&D ID
PD048045
CAS
2756-87-8
3052-50-4
Tags
available
covalent binder
drug
drug candidate
Drug indication
Discovery agent
Relapsing-remitting multiple sclerosis
Drug Status
approved
experimental
investigational
Max Phase
4.0
First approval
2020
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Monomethylfumarate (MMF) is the active metabolite of the approved drug (DMF).
DESCRIPTION
Monomethyl fumarate (MMF) is the active metabolite of the approved drug (DMF).
(GtoPdb)
DESCRIPTION
Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].
PRICE
29
DESCRIPTION
Nrf2 pathway activator; neuroprotective
(Tocris Bioactive Compound Library)
DESCRIPTION
Monomethyl fumarate is a metabolite of dimethyl fumarate. It is a potent immunosuppressants. It is a nuclear factor-like 2 pathway activator. Also, monomethyl fumarate exhibits agonist activity at GPR109A. Monomethyl fumarate suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases.
(Enamine Bioactive Compounds)
DESCRIPTION
Monomethyl fumarate is a potent agonist of GPR109A .
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
19
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
130.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.2
TPSA
63.6
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
0.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Drug Metabolite
GPR109A
Apoptosis related,Autophagy,GPR
Primary Target
Antioxidants
Indication
multiple sclerosis
Pathway
Endocrinology/Hormones
GPCR/G protein
Metabolism
Metabolic Enzyme/Protease
Source data
