General
Preferred name
monomethyl fumarate
Synonyms
monomethylfumarate ()
MMF ()
mono methyl fumarate ()
MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate ()
Methyl Fumarate ()
NSC-523835 ()
Fumaric acid monomethyl ester ()
Bafiertam ()
P&D ID
PD048045
CAS
2756-87-8
3052-50-4
Tags
covalent binder
drug candidate
natural product
drug
available
Drug Status
experimental
investigational
approved
Drug indication
Discovery agent
Max Phase
Phase 4
First approval
2020
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Monomethyl fumarate (MMF) is the active metabolite of the approved drug (DMF).
(GtoPdb)
DESCRIPTION
Monomethylfumarate (MMF) is the active metabolite of the approved drug (DMF).
DESCRIPTION
Nrf2 pathway activator; neuroprotective
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
130.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.2
TPSA
63.6
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
0.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Antioxidants
Indication
multiple sclerosis
Pathway
GPCR/G protein
Metabolic Enzyme/Protease
Target
Drug Metabolite
GPR109A
Apoptosis related,Autophagy,GPR
Source data
