General
Preferred name
SM-337
Synonyms
P&D ID
PD048043
CAS
1071992-61-4
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
SM-377 is compound 6 in . SM-337 is a potent, orally bioavailable Smac mimetic which acts as an antagonist of caspase binding to IAP family members, XIAP, cIAP1 and cIAP2 .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
11
Molecular Weight
595.32
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
9
Ring Count
5
Aromatic Ring Count
3
cLogP
2.82
TPSA
110.85
Fraction CSP3
0.37
Chiral centers
4.0
Largest ring
8.0
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
