General
Preferred name
ibutamoren
Synonyms
MK 0677 ()
MK-677 ()
MK-0677 ()
IBUTAMOREN MESYLATE ()
Ibutamoren mesylate (MK-677) ()
MK 677 ()
[35S]ibutamoren ()
Ibutamoren mesilate ()
Ibutamoren (Mesylate) ()
[35S]ibutamoren ()
L-163,191 ()
Ibutamoreno ()
P&D ID
PD047991
CAS
159752-10-0
159634-47-6
Tags
available
biased GPCR ligand
drug candidate
drug
Drug indication
Fibromyalgia
Growth Hormone Releasing Factor
Discovery agent
Drug Status
approved
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Potent and selective positive allosteric modulator of mGlu5 receptors (Tocris Bioactive Compound Library)
DESCRIPTION High affinity ghrelin receptor agonist (Tocriscreen Plus)
DESCRIPTION Ibutamoren, also known as MK-677 (L-163,191), is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels.It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
24
AdooQ Bioactive Compound Library
A12781
Axon Medchem Screening Library
1376
BiasDB
Ibutamoren
BOC Sciences Bioactive Compounds
ibutamoren-cas-159634-47-6-item-84-181230
Cayman Chemical Bioactives
18003
ChEMBL Drugs
CHEMBL2105872
CHEMBL13817
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB18214
DrugMAP
DMFJ8LT
DMQ0NK8
DrugMAP Approved Drugs
DMFJ8LT
EU-OPENSCREEN Bioactive Compound Library
EOS101128
EUbOPEN Chemogenomics Library
EUB0000425
Guide to Pharmacology
5867
1097
JUMP-Target 1 Compound Set
178024
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL13817
Mcule NIBR MoA Box Subset
MCULE-8989219658
MedChem Express Bioactive Compound Library
HY-50844
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
T7112
Tocris Bioactive Compound Library
5272
Tocriscreen Plus
5272
ZINC Tool Compounds
ZINC000001543181
External IDs
55
Properties
(calculated by RDKit )
Molecular Weight
528.24
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
2
cLogP
1.77
TPSA
122.04
Fraction CSP3
0.48
Chiral centers
1.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Pathway
GPCR/G protein
Target
GHSR
GHR, GHSR
GH secretagogue
Primary Target
Ghrelin Receptors
MOA
Agonist
Growth Hormone Secretagogues
growth hormone secretagogue receptor agonist
Member status
member
Recommended Cell Concentration
None
Source data