General
Preferred name
RU 24969
Synonyms
RU 24969 hemisuccinate ()
5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole ()
RU-24969 ()
RU 24969 (succinate) ()
5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole ()
RU 24969 free base ()
RU-24969 (succinate) ()
P&D ID
PD047960
CAS
66611-27-6
74163-68-1
107008-28-6
66611-26-5
Tags
available
drug candidate
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion[1].
PRICE
46
DESCRIPTION
RU 24969 succinate is a 5-HT receptor agonist with Ki values of 0.38 and 2.5 nM for 5-HT1B and 5-HT1A, respectively. RU 24969 decreases fluid consumption and increases forward locomotion. RU 24969 succinate can be used for the research of neurological disease[1][2][3][4].
DESCRIPTION
RU 24969 is a 5-hydroxytryptamine receptor inhibitor. RU 24969 could decrease fluid consumption and increase forward locomotion.
(Enamine Bioactive Compounds)
DESCRIPTION
RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole) is a selective agonist of 5-HT1A and 5-HT1B receptors.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Selective D2-like antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
5-HT1B/1A agonist
(Tocriscreen Total)
DESCRIPTION
RU 24969 hemisuccinate is a potent and selective agonist at the 5-HT1A and 5-HT1B receptors. It is centrally active following systemic administration.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
228.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
2.55
TPSA
37.05
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT
5-HT Receptor
HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, HTR6
Primary Target
5-HT1A Receptors
MOA
Agonist
5-HT1A Receptor Agonists
5-HT1B Agonists
serotonin receptor agonist
Member status
virtual
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data
